![]() ![]() ![]() This case highlights the potential use of idarucizumab for the management of massive dabigatran overdoses.ĭabigatran idarucizumab nonvitamin K antagonist oral anticoagulants overdose reversal. The initially planned emergency hemodialysis was canceled. ![]() The effect of warfarin has great inter- and intra-individual variation based on a variety of genetic, dietary, and medication effects. The administration of 5 g of intravenous idarucizumab promptly and completely reversed the anticoagulant activity of dabigatran as assessed by routine and specific coagulation assays (aPTT from to 75 to 26 s, PT from 26 to 11 s and diluted thrombin time from 92 to 27 s). Choice and dose is dependent on the clinical problem-no bleeding vs. Warfarin is associated with an increased risk of bleeding, as are a variety of other anticoagulants. 562 patients with INR of 6.0 to 10.0, withholding 2. Despite gastric lavage and administration of activated charcoal within two hours of drug intake, the activated partial thromboplastin time (aPTT) and prothrombin time (PT) remained prolonged. Withdrawal of warfarin results in a slow return of supratherapeutic INR values to the therapeutic range. We describe the use of idarucizumab in the management of a 68-year-old woman who was taking dabigatran 150 mg twice daily and ingested 125 capsules. It reverses the anticoagulant effect of dabigatran within minutes and is approved for the reversal of dabigatran during emergency situations. Idarucizumab is an antibody fragment that binds dabigatran with high affinity. The lack of an antidote is a concern in patients who overdose on dabigatran, even though the drug can be eliminated with hemodialysis. ![]() Dabigatran, an oral direct thrombin inhibitor, is increasingly used in place of warfarin. An overdose of oral anticoagulants represents a challenging scenario for emergency physicians. Warfarin (Coumadin), unfractionated heparin, and low-molecular-weight heparin (LMWH) are commonly used for the prevention and treatment of disorders such as systemic embolism associated with. ![]()
0 Comments
Leave a Reply. |